Masters Thesis Part 1: Primate Experiments

My computer science thesis work (PDF) at the Rochester Institute of Technology involved analyzing the firing rate response patterns of neurons in the Medial Superior Temporal (MST) region of Rhesus monkeys, which resides above the temple on both sides of the skull. The primate experiments were performed by Dr. Charles Duffy and Dr. William Page at the University of Rochester Neuroscience Department.

Each primate was trained to sit in a special chair and stare directly at a red dot in the center of a rear projection screen covering 90 deg. x 90 deg. of his visual field. The rest of the screen was black. The primate was rewarded with sweet juice if he remained still and stared at the dot for 5 minutes. After successfully completing this task various patterns of moving white dots were shown in the screen, like snow in the wind (except with uniform density and constant velocity). The screen was divided into 9 segments (like the side of a traditional Rubik's cube). Each dot would appear at one edge of the screen and travel in a certain pattern before exiting at another edge of the screen.

The simplest patterns consisted of linear motion where all of the dots moved in the same vertical or horizontal direction across one of the 9 screen segments. More complex patterns consisted of linear motion in 2 of the 9 screen segments where the dots could be moving in different directions within each segment. The most complex patterns were designed to simulation self-motion and occupied all 9 of the screen segments. For example, imagine the old Windows starfield screensaver where the dots travel from the center of the screen outwards, which makes you feel like you're moving into the screen. A cylindrical piece of the primate's skull cap was removed and an electrode was positioned to record individual neuron firing rate responses as the primate perceived each moving pattern on screen.

My task was to design a mathematical model capable of predicting how the primate responded to self-motion patterns given his response to simpler patterns in regards to individual MST neurons. Why? To further our understanding the mammalian brain. Such a biologically-inspired model can potentially be used to program the AI for more realistic robots, or potentially be used to program the firmware for a cybernetic implant to help treat the sensory degradation symptoms of Alzheimer's disease patients.

Note that firing rate signals were captured in a region of the brain before any higher level cognition was performed. In other words, the response values were not affected by what the primate was thinking about when viewing the patterns on screen (i.e. bananas). Well, in theory that's what we'd like to believe.